| Date | Teams | Players | |
| 3/1/2008 | San Jose | sends | Travis Buck |
| 3/1/2008 | Honker Bay | for | Pedro Feliz |
| 3/1/2008 | Cooperston | sends | Wladimir Balentien |
| 3/1/2008 | Thunder Valley | for | Aaron Laffey, Matt Chico |
| 3/1/2008 | East Bay | sends | Ryan Franklin, Joey Gathright |
| 3/1/2008 | Honker Bay | for | Dimitri Young |
| 3/1/2008 | San Jose | sends | Jo-Jo Reyes, Joel Peralta |
| 3/1/2008 | Cooperstown | for | Matt Chico |
| 3/1/2008 | Cooperstown | sends | Brian Wolfe |
| 3/1/2008 | Honker Bay | for | Taylor Buchholz, Brad Hennessey |
| 3/1/2008 | Mount Diablo | sends | MD #6 |
| 3/1/2008 | Thunder Valley | for | Ramon Pena |
| 3/1/2008 | Thunder Valley | sends | Ivan Rodriguez |
| 3/1/2008 | St. Paul | for | SP #8 |
| 3/9/2008 | Texas | sends | Todd Helton |
| 3/9/2008 | Cantrell | for | Aaron Rowand, Taylor Tankersley |
| 3/9/2008 | Mount Diablo | sends | Matt Holliday, Michael Young, Zach Greinke, Huston Street |
| 3/9/2008 | Honker Bay | for | Curtis Granderson, Hanley Ramirez, David Riske, Jeremy Accardo |
| 3/9/2008 | East Bay | sends | Adam Loewen, EB #2 |
| 3/9/2008 | Cantrell | for | Kelvim Escobar |
| 6/8/2008 | Cantrell | sends | Bobby Abreu |
| 6/8/2008 | St. Paul | for | J.D. Drew, Scott Linebrink, SP #5 |
| 6/8/2008 | Mount Diablo | sends | David Ortiz, Brad Penny, JJ Putz, Jeremy Accardo, Mark Ellis |
| 6/8/2008 | St. Paul | for | Brandon Phillips, Fausto Carmona, George Sherrill, Jorge Cantu, SP #2 |
| 6/8/2008 | Texas | sends | Roy Oswalt |
| 6/8/2008 | St. Paul | for | Kevin Millwood, SP #1 |
| 6/9/2008 | Cooperstown | sends | Edgar Renteria |
| 6/9/2008 | St. Paul | for | Orlando Cabrera, SP #3, SP #4 |
| 6/9/2008 | Cooperstown | sends | Tim Hudson, Chien-Ming Wang |
| 6/9/2008 | California | for | Felix Hernandez, Ross Detwiler, CQ #4 |
| 6/12/2008 | Bodega Bay | sends | MD #8 |
| 6/12/2008 | Mount Diablo | for | Woody Williams |
| 6/21/2008 | East Bay | sends | Francisco Liriano, Mark Reynolds, EB #1, EB #6 |
| 6/21/2008 | Mount Diablo | for | Chipper Jones, Fausto Carmona, David Riske, MD #2 |
| 6/22/2008 | Bodega Bay | sends | Ryan Spilborghs, David Ross |
| 6/22/2008 | Wisconsin | for | Yadier Molina |
| 7/13/2008 | Bodega Bay | sends | Andy Sonnanstine, BB #3 |
| 7/13/2008 | Cantrell | for | Rafael Betancourt, Damaso Marte |
| 7/26/2008 | Cantrell | sends | AJ Burnett, Troy Tulowitzki, Manny Acosta, SP #5, CS #6, CS #7, CS #8 |
| 7/26/2008 | Honker Bay | for | Zack Greinke, Joe Beimel, Mike Young, HB #1, HB #3 |
| 7/28/2008 | Thunder Valley | sends | Gary Sheffield |
| 7/28/2008 | Honker Bay | for | HB #4 |
| 7/30/2008 | California | sends | Delmon Young, Yovani Gallardo, CQ #3 |
| 7/30/2008 | Thunder Valley | for | Milton Bradley, Manny Parra, Jason Varitek |
| 9/13/2008 | East Bay | sends | Ryan Sweeney |
| 9/13/2008 | San Jose | for | SJ #1 |
| 9/15/2008 | San Jose | sends | Michael Cuddyer, Eric Byrnes |
| 9/15/2008 | Texas | for | TR #6, TR #8 |
| 9/15/2008 | San Jose | sends | Tom Gorzelanny |
| 9/13/2008 | Silcon Forest | for | SF #5 |